Gene Transfer with Poly-Melittin Peptides
نویسندگان
چکیده
منابع مشابه
Gene Transfer Enhancement by Alkylcarboxylation of Poly(propylenimine)
Abstract Among synthetic carriers, dendrimers with the more flexible structure have attracted a great deal of researchers’ attention in the field of gene delivery. Followed by the promising results upon hydrophobic modification on polymeric structures in our laboratory, alkylcarboxylated poly (propylenimine)-based carriers were synthesized by nucleophilic substitution of amines with alkyl moiet...
متن کاملDesign and bioinformatics analysis of novel biomimetic peptides as nanocarriers for gene transfer
Objective(s): The introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. For several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....
متن کاملgene transfer enhancement by alkylcarboxylation of poly(propylenimine)
abstract among synthetic carriers, dendrimers with the more flexible structure have attracted a great deal of researchers' attention in the field of gene delivery. followed by the promising results upon hydrophobic modification on polymeric structures in our laboratory, alkylcarboxylated poly (propylenimine)-based carriers were synthesized by nucleophilic substitution of amines with alkyl moiet...
متن کاملThe influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
The process by which viruses destabilize endosomal membranes in an acidification-dependent manner has been mimicked with synthetic peptides that are able to disrupt liposomes, erythrocytes, or endosomes of cultured cells. Peptides containing the 20 amino-terminal amino acid sequence of influenza virus hemagglutinin as well as acidic derivatives showed erythrocyte lysis activity only when peptid...
متن کاملdesign and bioinformatics analysis of novel biomimetic peptides as nanocarriers for gene transfer
objective(s): the introduction of nucleic acids into cells for therapeutic objectives is significantly hindered by the size and charge of these molecules and therefore requires efficient vectors that assist cellular uptake. for several years great efforts have been devoted to the study of development of recombinant vectors based on biological domains with potential applications in gene therapy....
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ژورنال
عنوان ژورنال: Bioconjugate Chemistry
سال: 2006
ISSN: 1043-1802,1520-4812
DOI: 10.1021/bc060028l